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DRESS syndrome with acute interstitial nephritis caused by quinolone and non-steroidal anti-inflammatory drugs / 영남의대학술지
Yeungnam University Journal of Medicine ; : 59-63, 2016.
Artículo en Coreano | WPRIM | ID: wpr-60375
ABSTRACT
Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a rare and severe drug-induced hypersensitivity syndrome characterized by hematological abnormalities and multiorgan involvement. Liver involvement is the most common visceral manifestation. However, renal failure has been rarely described. The common culprit drugs are anticonvulsants and allopurinol. We experienced a patient with DRESS syndrome with acute interstitial nephritis caused by concomitant administration of quinolone and non-steroidal anti-inflammatory drugs (NSAIDs). A 41-year-old man presented with a diffuse erythematous rash and fever which developed after administration of quinolone and NSAIDs for a month due to prostatitis. He was diagnosed with DRESS syndrome. Skin rash, fever, eosinophilia, and elevations of liver enzymes improved with conservative treatment and discontinuation of the causative drugs. However, deterioration of his renal function occurred on day 8 of admission. The levels of blood urea nitrogen and serum creatinine increased and oliguria, proteinuria and urinary eosinophils were observed. Ultrasonography showed diffuse renal enlargement. The clinical features were compatible with acute interstitial nephritis. Despite intravenous rehydration and diuretics, renal function did not improve. After hemodialysis, his renal function recovered completely within 2 weeks without administration of systemic corticosteroid.
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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Oliguria / Prostatitis / Proteinuria / Nitrógeno de la Urea Sanguínea / Antiinflamatorios no Esteroideos / Alopurinol / Ultrasonografía / Diálisis Renal / Creatinina / Diuréticos Tipo de estudio: Estudio diagnóstico Límite: Adulto / Humanos Idioma: Coreano Revista: Yeungnam University Journal of Medicine Año: 2016 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Oliguria / Prostatitis / Proteinuria / Nitrógeno de la Urea Sanguínea / Antiinflamatorios no Esteroideos / Alopurinol / Ultrasonografía / Diálisis Renal / Creatinina / Diuréticos Tipo de estudio: Estudio diagnóstico Límite: Adulto / Humanos Idioma: Coreano Revista: Yeungnam University Journal of Medicine Año: 2016 Tipo del documento: Artículo