The expression and clinical significance of microRNA -22 in gastric cancer / 中国基层医药

ABSTRACT

Objective To investigate the expression and clinical value of miRNA -22 in gastric cancer tissues.Methods Real -time PCR was used to detect the miRNA -22 expression in gastric cancer tissues and matched adjacent tissues.The correlations of miRNA -22 expression with clinic pathological features were analyzed. Results 87.5%(77 /88)of the gastric tumor tissues showed aberrant down regulation of miRNA -22 compared with adjacent non -tumor tissues (χ2 =69.32,P 0.05 ). Conclusion The lower expression of miRNA -22 is associated with clinic pathological features.