Expression of PTEN in Myocardial Tissue in Coronary Heart Disease / 法医学杂志
Journal of Forensic Medicine
;
(6): 94-96,104, 2016.
Artículo
en Chino
| WPRIM
| ID: wpr-604727
ABSTRACT
Objective To observe the expression of phosphatase and tensin hom ology deleted on chrom o-som e ten (PTEN) in m yocardial tissue in patients w ith coronary heart disease, and explore the relevance betw een the expression of PTEN and the occurrence and developm ent of coronary heart disease. Methods A total of 16 death cases w ith pathological diagnosis of coronary heart disease w ere collected as experi-m ental group, and 19 cases w ithout m yocardial lesions w ere selected as control group. The expression of PTENprotein and its m RNA w ere detected by im m unohistochem istry and real-tim e fluorescence quanti-tative PC R respectively. The correlation betw een the expression of PTEN and the pathogenesis of coronary heart disease w as analyzed. Results The expression of PTENprotein in myocardium in cases w ith coro-nary heart disease w as significantly low er com pared w ith the control group (P0.05). Conclusion PTEN m ay be involved in the occurrence and developm ent of coronary heart disease.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
Journal of Forensic Medicine
Año:
2016
Tipo del documento:
Artículo
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