Clinical Observation of Carbamazepine Combined with Topiramate in the Treatment of Partial Epilepsy / 中国药房
China Pharmacy
;
(12): 4213-4214,4215, 2015.
Artículo
en Chino
| WPRIM
| ID: wpr-605211
ABSTRACT
OBJECTIVE:
To observe the efficacy and safety of carbamazepine combined with topiramate in the treatment of par-tial epilepsy.METHODS:
130 patients with partial epilepsy were randomly divided into observation group and control group. Con-trol group was orally treaed with carbamazepine 100 mg,3 times a day. Based on the treatment of control group,observation group was orally treaed with topiramate initial dose of 25 mg,once a day,and then increased 25 mg every week,the maximum dose was no more than 200 mg,once a day. After 6 months,the efficacy was evaluated,frequency of epileptic seizures,EEG epileptiform discharges wave and incidence of adverse reactions were observed.RESULTS:
The total effective rate in observation group was sig-nificantly higher than control group(P0.05).CONCLUSIONS:
Carbamazepine combined with topiramate has better efficacy than carbamazepine alone in the treatment of partial epilepsy,with similar safety.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
China Pharmacy
Año:
2015
Tipo del documento:
Artículo
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