Expression and Clinicopathological Significance of N-cadherin in the Ovarian Carcinoma / 现代生物医学进展
Progress in Modern Biomedicine
; (24): 4361-4364, 2017.
Article
en Zh
| WPRIM
| ID: wpr-606849
Biblioteca responsable:
WPRO
ABSTRACT
Objective:To explore the expression of N-cadherin and its correlations with the clinicopathological features of human ovarian carcinoma.Methods:The expression of N-cadherin in 281 cases of ovarian carcinoma tissues were determined by immunohistochemical method.The correlations of N-cadherin expression with the clinicopathological features of human ovarian carcinoma were analyzed.Results:There was higher expression of N-cadherin in the metastatic lesions than its paired primary lesions (P =0.018).The expression level of N-cadherin in ovarian carcinoma was correlated with the FIGO stage (P =0.034),histological type (P <0.001) and tumor grade (P =0.004).Conclusions:High expression of N-cadherin might positively correlate with the invasion and migration ability of ovarian carcinoma cells,which was more common in the the advanced (FIGO Ⅱ-Ⅳ) ovarian carcinoma,high-grade serous carcinoma,and high grade ovarian carcinoma.N-cadherin might be useful in estimating the biological behavior of human ovarian carcinoma.
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WPRIM
Idioma:
Zh
Revista:
Progress in Modern Biomedicine
Año:
2017
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Article