Application of next-generation sequencing in research and personalized treatment of glioma / 第二军医大学学报

ABSTRACT

Glioma is a highly lethal malignancy and multiple challenges remain for it in the genomic study and clinical treatment.Next-generation sequencing (NGS) holds many advantages,and NGS can comprehensively analyze the whole genome,exome,transcriptome and epigenome to deepen the understanding of tumor genomics;and now,it has been successfully applied in the clinical study of some tumors,especially in personalized treatment for these tumors.At present,NGS has also been a hot in glioma research to clarify the pathogenesis of glioma,so as to draw up a personalized treatment method to benefit the patients.