The Immunohistochemical Patterns of the beta-Catenin Expression in Pilomatricoma
Annals of Dermatology
;
: 284-289, 2010.
Artículo
en Inglés
| WPRIM
| ID: wpr-60736
ABSTRACT
BACKGROUND:
Pilomatricoma is a benign follicular tumor that is composed of basaloid cells, transitional cells and shadow cells. beta-Catenin is a 92-kDa protein, and it plays important roles in cell-cell adhesion at the cell membrane and signal transduction in the nucleus. beta-Catenin has recently been shown to play an important role in the formation of hair follicle-related tumors, including pilomatricoma. However, the pattern and the intracellular localization of the beta-Catenin expression are still controversial.OBJECTIVE:
We wanted to evaluate the pattern and the intracellular localization of the beta-Catenin expression in pilomatricoma by performing immunohistochemical staining.METHODS:
Twenty-seven paraffin-embedded tissue samples that were diagnosed as pilomatricoma were immunohistochemically stained with beta-Catenin antibody.RESULTS:
Basaloid cells were found 15 samples of the total 27 pilomatricomas. All (15/15) of the basaloid cells strongly expressed beta-Catenin, but the transitional cells and the shadow cells did not. In the basaloid cells, the nuclei and membranes showed prominent beta-Catenin immunoreactivities, but the cytoplasm showed weak beta-Catenin immunoreactivity.CONCLUSION:
This study confirmed that the nucleus and membrane of all the basaloid cells in the pilomatricomas showed a strong beta-Catenin expression, but the transitional cells and shadow cells showed negative beta-Catenin immunoreactivity.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Transducción de Señal
/
Membrana Celular
/
Pilomatrixoma
/
Citoplasma
/
Beta Catenina
/
Cabello
/
Membranas
Idioma:
Inglés
Revista:
Annals of Dermatology
Año:
2010
Tipo del documento:
Artículo
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