Gd-BOPTA enhanced MRI in evaluation of reserved liver function / 中国医学影像技术

ABSTRACT

Objective To investigate the value of gadobenate dimeglumine (Gd-BOPTA) enhanced MRI in evaluation of reserved liver function.Methods Totally 68 patients were included among 143 patients who underwent Gd-BOPTA en hanced MRI.The enhancement ratios of SNR and CNR of right lobe,left lobe and caudal lobe were calculated on the ima ges from liver acquisition with volume acceleration flex sequence (LAVA-Flex) of hepatobiliary phase.The average values of right and left lobes and of three lobes were calculated and compared.According to Child-TurcottePugh (CTP) classification,the patients were divided into Class A and Class B.Integrated model of end-stage liver disease (iMELD) was applied to divide the patients into iMELD≤30 and iMELD＞30.The differences of SNR and CNR enhanced ratios were com pared,and the relationship between enhancement ratios and iMELD scores was analyzed.Results There were no significant differences in the enhancement ratios of SNR and CNR among each lobe,the average of two or three lobes (all P＞0.05).The SNR and CNR enhancement ratios of Class A were higher than those of Class B (both P＜0.05).The SNR and CNR enhancement ratios of iMELD≤≤30 were higher than those of iMELD＞30 (both P＜0.05).The SNR and CNR enhancement ratios showed negative correlations with iMELD scores (SNRr=0.29,P-0.02;CNRr=-0.32,P=0.01).Conclusion The intracellular uptake of Gd-BOPTA decreases with impaired liver function.Measurement of the de gree of parenchymal enhancement of any lobe or the whole liver on the images of Gd-BOPTA enhancement MRI in the hepatobiliary phase might reflect the reserved liver function.