Your browser doesn't support javascript.
loading
Molecular Motor Proteins of the Kinesin Superfamily Proteins (KIFs): Structure, Cargo and Disease
Journal of Korean Medical Science ; : 1-7, 2004.
Artículo en Inglés | WPRIM | ID: wpr-60901
ABSTRACT
Intracellular organelle transport is essential for morphogenesis and functioning of the cell. Kinesins and kinesin-related proteins make up a large superfamily of molecular motors that transport cargoes such as vesicles, organelles (e.g. mitochondria, peroxisomes, lysosomes), protein complexes (e.g. elements of the cytoskeleton, virus particles), and mRNAs in a microtubule- and ATP-dependent manner in neuronal and non-neuronal cells. Until now, more than 45 kinesin superfamily proteins (KIFs) have been identified in the mouse and human genomes. Elucidating the transport pathways mediated by kinesins, the identities of the cargoes moved, and the nature of the proteins that link kinesin motors to cargoes are areas of intense investigation. This review focuses on the structure, the binding partners of kinesins and kinesin-based human diseases.
Asunto(s)

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Unión Proteica / Transporte Biológico / Adenosina Trifosfato / Cinesinas / Citoplasma / Diabetes Mellitus / Enfermedad de Alzheimer / Proteínas Asociadas a Microtúbulos / Microtúbulos / Modelos Biológicos Límite: Animales / Humanos Idioma: Inglés Revista: Journal of Korean Medical Science Año: 2004 Tipo del documento: Artículo

Similares

MEDLINE

...
LILACS

LIS

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Unión Proteica / Transporte Biológico / Adenosina Trifosfato / Cinesinas / Citoplasma / Diabetes Mellitus / Enfermedad de Alzheimer / Proteínas Asociadas a Microtúbulos / Microtúbulos / Modelos Biológicos Límite: Animales / Humanos Idioma: Inglés Revista: Journal of Korean Medical Science Año: 2004 Tipo del documento: Artículo