Relationship between Autophagy Abnormalities and Pathogenesis of Inflammatory Bowel Disease / 胃肠病学

ABSTRACT

Autophagy dysfunction is present in patients with inflammatory bowel disease (IBD), and the single-nucleotide polymorphisms (SNP) of autophagy related genes ATG16L1, NOD2 and IRGM might contribute to an increased susceptibility to IBD.Autophagy might participate in the pathogenesis of IBD through immune response and tolerance, intracellular bacterial infection, abnormalities in immune regulation and Paneth cells, and endoplasmic reticulum stress.This article reviewed the relationship between autophagy abnormalities and pathogenesis of IBD.