Role of myosin regulatory light chain phosphorylation in the pathogenesis of chronic heart failure / 上海交通大学学报(医学版)
Journal of Shanghai Jiaotong University(Medical Science)
; (12): 1165-1168, 2017.
Article
en Zh
| WPRIM
| ID: wpr-610461
Biblioteca responsable:
WPRO
ABSTRACT
In the embryonic period, myosin regulatory light chain (MYL2) plays a pivotal role in the development and function of the heart. A large number of studies have previously confirmed that the mutation of MYL2 gene, also known as MLC2, confers intimate associations with hypertrophic cardiomyopathy. MYL2 gene mutation impacts the structure and function of myosin, thereby leading to the occurrence and progression of hypertrophic and dilated cardiomyopathy as well as the following chronic heart failure. Importantly, MYL2 phosphorylation renders crucial effects in the processes of cardiac contraction, ventricular torsion and cardiac function.
Texto completo:
1
Índice:
WPRIM
Tipo de estudio:
Etiology_studies
Idioma:
Zh
Revista:
Journal of Shanghai Jiaotong University(Medical Science)
Año:
2017
Tipo del documento:
Article