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Antiemetic effect of propofol administered at the end of surgery in laparoscopic assisted vaginal hysterectomy / 대한마취과학회지
Korean Journal of Anesthesiology ; : 210-215, 2014.
Artículo en Inglés | WPRIM | ID: wpr-61145
ABSTRACT

BACKGROUND:

Postoperative nausea and vomiting (PONV) commonly occur after general anesthesia, especially in women. In this study, we evaluated the antiemetic efficacy of propofol administered at the end of surgery in highly susceptible patients undergoing a laparoscopy-assisted vaginal hysterectomy.

METHODS:

A total of 107 women undergoing a laparoscopy-assisted vaginal hysterectomy under general anesthesia were enrolled for this prospective, double-blind, randomized study. Fifteen minutes before the end of surgery, all patients received 50 microg fentanyl and 1 of following 3 doses; 0.5 mg/kg of propofol (propofol 0.5 group), 1 mg/kg of propofol (propofol 1.0 group), and normal saline (control group). All patients received intravenous patient-controlled analgesia (PCA). Emergence time, a visual analog scale for pain and nausea, duration of postanesthesia care unit (PACU) stay, and frequency of antiemetic use were recorded at 0-2, 2-24, and 24-48 hours postoperatively.

RESULTS:

The incidence of nausea significantly lower in the propofol 0.5 and propofol 1.0 groups than in the control group (12.1 vs 14.7 vs 40%). During the first postoperative 2 hours, antiemetics were less frequently administered in the propofol 0.5 and propofol 1.0 groups than in the control group (3.0 vs 5.9 vs 22.5%). Emergence time was slightly longer in the propofol 0.5 and propofol 1.0 groups than in the control group, but there was no significant difference in PACU stay time was observed between the 3 groups.

CONCLUSIONS:

The results of this study suggest that low-dose propofol administration at the end of surgery may effectively reduce the incidence of PONV within 2 hours postoperatively in highly susceptible women undergoing a laparoscopiy-assisted vaginal hysterectomy and receiving opioid-based PCA.
Asunto(s)

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Anafilaxis Cutánea Pasiva / Propofol / Fentanilo / Incidencia / Estudios Prospectivos / Analgesia Controlada por el Paciente / Laparoscopía / Náusea y Vómito Posoperatorios / Escala Visual Analógica / Histerectomía Vaginal Tipo de estudio: Ensayo Clínico Controlado / Estudio de incidencia / Estudio observacional / Estudio pronóstico Límite: Femenino / Humanos Idioma: Inglés Revista: Korean Journal of Anesthesiology Año: 2014 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Anafilaxis Cutánea Pasiva / Propofol / Fentanilo / Incidencia / Estudios Prospectivos / Analgesia Controlada por el Paciente / Laparoscopía / Náusea y Vómito Posoperatorios / Escala Visual Analógica / Histerectomía Vaginal Tipo de estudio: Ensayo Clínico Controlado / Estudio de incidencia / Estudio observacional / Estudio pronóstico Límite: Femenino / Humanos Idioma: Inglés Revista: Korean Journal of Anesthesiology Año: 2014 Tipo del documento: Artículo