The impact of inflammatory cytokines and therapy effect of ecabet sodium quadruple therapy for patients with duodenal ulcer / 中国生化药物杂志

ABSTRACT

Objective To study the effect of inflammatory cytokines and therapy effect of ecabet sodium quadruple therapy for patients with duodenal ulcer.Methods80 cases patients with H.pylori-positive ulcer duodenal in In our hospital In our hospital April 2015 to December 2016 were randomLy divided into observation group 42 cases and control group 38 cases, the observation group were treated with ecabet sodium quadruple therapy, the control group were treated with colloidal bismuth pectin quadruple therapy.Then therapy effect, H.pylori eradication rate, inflammatory cytokines, adverse reactions were compared between two groups.ResultsUlcer healing: the observation group total effective rate 97.62% was significantly higher than the control group 78.95% (χ2=6.966, P<0.05);Hp eradicate rate: the observation group Hp eradicate rate 95.24% was significantly higher than that of control group 76.32%(χ2=6.023, P<0.05);Serum inflammatory factors: observation group serum TNF-α, IL-6, IL-8 levels were significantly lower than the control group(t =4.272, 7.584, 3.095, P<0.05);Adverse reaction: observation group adverse reactions 7.14% was significantly lower than the control group 23.68%(χ2=4.281, P<0.05).ConclusionEcabet sodium quadruple therapy helps to reduce serum inflammatory factor expression level, then improve therapy effect and reduce adverse reactions.