Research progresses of the effective mechanism of pyroptosis and its related diseases / 医学研究生学报
Journal of Medical Postgraduates
; (12): 648-652, 2017.
Article
en Zh
| WPRIM
| ID: wpr-612953
Biblioteca responsable:
WPRO
ABSTRACT
Pyroptosis is a newly discovered form of programmed cell death, which has a close relationship with infectious diseases and spontaneous inflammatory disease and autoimmune disease.Gasdermin-D is the effector of pyroptosis.Inflammatory caspases cleave Gasdermin-D, break the structural autoinhibition and active the pore-forming activity of Gasdermin-D.Gasdermin-D-N domain is the active form of Gasdermin-D.Oligomerized Gasdermin-D-N domain forms membrane pores.Both pyroptosis and necroptosis can form pores.In this article, the progress of the research on pyroptosis, the involvement of Gasdermin-D in the molecular mechanism of pyroptosis, the distinguishment of pyroptosis from necroptosis and pyroptosis-related diseases are reviewed.
Texto completo:
1
Índice:
WPRIM
Idioma:
Zh
Revista:
Journal of Medical Postgraduates
Año:
2017
Tipo del documento:
Article