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Comparative Study of Cystatin C and Its Gene Polymorphism of Patients with Coronary Heart Disease between Zhuang and Han in Guangxi Region / 现代检验医学杂志
Journal of Modern Laboratory Medicine ; (4): 26-29,33, 2017.
Artículo en Chino | WPRIM | ID: wpr-613511
ABSTRACT
Objective To investigate the difference of serum levels of cystatin C and its gene polymorphism of patients with CHD and normal people between Zhuang and Han in Guanxi region.Methyds The levels of serum cystatin C in Zhuang CHD patients,Han CHD patients,Zhuang normal people and Han normal people(each of 100 cases)were detected by Immunoturbidimetric Assays,Cys C + 148 and Cys C-82 genotypes were conducted by using PCR-RFLP,and that data and clinical data were analyzed.Results The difference of Cys C levels and clinical data between two CHD groups and two normal groups were statically significant (all P<0.05).①The Cys C levels of two CHD groups was not statically significant difference (P=0.156).②The CysC+148 and Cys C-82 of 4 groups conform the Hardy-Weinberg population genetic equilibrium law (all P>0.05).The genotypes frequency difference of Cys C+148 and Cys C-82 between two CHD groups and two normal group were no statically significant (x2 =0.760~2.090,P>0.05).③The serum Cys C level and Cr of CHD group were positively correlated (r=0.597,P<0.001).Conclusion The correlation Cys C+ 148,-82 polymorphism and Guangxi Zhuang CHD were in need of further study,but the kidney damage caused by the high serum Cys C level may be a risk factor for Guangxi Zhuang and Han CHD patients.

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Tipo de estudio: Factores de riesgo Idioma: Chino Revista: Journal of Modern Laboratory Medicine Año: 2017 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Tipo de estudio: Factores de riesgo Idioma: Chino Revista: Journal of Modern Laboratory Medicine Año: 2017 Tipo del documento: Artículo