Curative efficacy of carboprost romethamine in treatment of postpartum hemorrhage of pregnancy and its effects on fibrinogen and D-dimer / 中国生化药物杂志

ABSTRACT

Objective To study curative efficacy of carboprost romethamine in treatment of postpartum hemorrhage of pregnancy and its effects on fibrinogen(FIB) and D-dimer(D-D).Methods106 patients of chronic renal failure who received therapy from November 2015 to November 2016 in our hospital were selected.According to random number table, those patients were divided into the observation group (n=53) and the control group (n=53).The control group was treated with oxytocin after delivery, while the observation group was treated with carboprost romethamine.The postoperative 2h and 24h bleeding volume, contraction duration, duration of lochia, uterus decreased speed and the changes of FIB and D-D before and after treatment were compared, and comparison of adverse reactions.ResultsThe postoperative 2h and 24h bleeding volume in the observation group were significantly lower than those in the control group[(231.58±36.79)mL vs (345.62±45.60)mL, (301.24±44.01)mL vs (445.23±61.74)mL] (P<0.05);compared with the control group, the observation group contraction duration longer, duration of lochia was shorter, uterus decreased was faster(P<0.05);before treatment, there was no significant difference in FIB and D-D between the two groups;after treatment, the levels of FIB and D-D in the control group did not change significantly;the levels of FIB and D-D in the observation group were significantly reduce, and the result were lower than those in the control group(P<0.05);there was no significant difference in the incidence of nausea and vomiting, chest pain, chills between the two groups.ConclusionCarboprost romethamine is well for postpartum hemorrhage of pregnancy, which can effectively improve blood hypercoagulable state, reduce the amount of postpartum hemorrhage, it's worthy of application and promotion.