Visual Function Test for Early Detection of Ethambutol-Induced Ocular Toxicity
Journal of the Korean Ophthalmological Society
; : 694-699, 2012.
Article
en Ko
| WPRIM
| ID: wpr-61432
Biblioteca responsable:
WPRO
ABSTRACT
PURPOSE: The purpose of the present study was to investigate various visual function tests for early detection of ethambutol-induced ocular toxicity. METHODS: A prospective study of 20 eyes of 10 patients being treated with ethambutol was conducted. Visual acuity, visual field, color vision, fundus examination, contrast sensitivity, optical coherence tomography (OCT), and pattern-visual evoked potential (VEP) were assessed. Examinations were performed prior to therapy and every month for 5 months after treatment. VEP was performed every other month. The mean values of each parameter at each month were compared with the baseline examination and a p-value of <0.05 was considered significant. In addition, a greater than 2 standard deviation (SD) change in each parameter from the mean values at baseline was considered as an ocular toxicity induced change in each individual eye. RESULTS: On OCT, a significant increase of the average retinal nerve fiber layer thickness was detected after 4 months of therapy. VEP showed an increased mean latency of the P100 wave after 2 and 4 months of therapy. However, a greater than 2 SD change from the mean values of the baseline was not observed on OCT, while 30% (6/20) of the eyes showed more than a 2 SD increase in VEP latency. Visual acuity, color vision, fundus, contrast sensitivity, and visual field were not affected in any patients. CONCLUSIONS: The authors of the present study consider VEP as a sensitive test to detect early toxicity of ethambutol. VEP can be helpful in identifying subclinical ocular toxicity, especially in the high-risk patients.
Palabras clave
Texto completo:
1
Índice:
WPRIM
Asunto principal:
Retinaldehído
/
Sensibilidad de Contraste
/
Agudeza Visual
/
Campos Visuales
/
Estudios Prospectivos
/
Tomografía de Coherencia Óptica
/
Etambutol
/
Potenciales Evocados
/
Potenciales Evocados Visuales
/
Ojo
Tipo de estudio:
Diagnostic_studies
/
Observational_studies
/
Screening_studies
Límite:
Humans
Idioma:
Ko
Revista:
Journal of the Korean Ophthalmological Society
Año:
2012
Tipo del documento:
Article