Relationship between serum levels of MMP-9 and TNF-α with bone turnover biochemical indicators andbone mineral density in patients with chronic obstructive pulmonary disease / 国际检验医学杂志

ABSTRACT

Objective To investigate the relationship between serum matrix metalloproteinase(MMP-9) and tumor necrosis factor alpha(TNF-α) with bone turnover markers and bone mineral density(BMD) in the patients with chronic obstructive pulmonary disease(COPD) complicating osteoporosis.Methods Eighty-four cases of stable stage of COPD admitted to our hospital were selected and divided into the osteoporosis group(28 cases),low bone mass group(26 cases) and normal bone mass group(30 cases) according to the BMD detection results.ELISA was adopted to detect the MMP-9,TNF-α,bone turnover biochemical markers sBAP,sOC and sCTX levels.Results Serum MMP-9,TNF-α levels in the osteoporosis group and low bone mass group were higher than those in the normal bone mass group,which in the osteoporosis group were higher than those in the low bone mass group,the differences were statistically significant(P<0.05);the sBAP and sOC levels in the osteoporosis group was lower than those in the normal bone mass group,while the sCTX level was higher than that of the normal bone mass group;the sBAP and sOC levels in the low bone mass group were lower than those in the normal bone mass group,the sBAP level in the osteoporosis group was lower than that in the low bone mass group,the sCTX level was higher than that of low bone mass group,the differences were statistically significant(P<0.05);the lumbar vertebral BMD and its T value,femoral neck BMD and its T value in the osteoporosis group and low bone mass group were lower than those in the normal bone mass group(P<0.05),which in the osteoporosis group were lower than those in the low bone mass group(P<0.05);serum MMP-9 was negatively correlated with bone turnover biochemical markers and BMD level(P<0.05);TNF-α was negatively correlated with bone turnove biochemical markers(P<0.05).Conclusion MMP-9 and TNF-α are highly expressed in the patients with COPD complicating osteoporosis,and negatively correlated with the bone bone turnove biochemical markers,meanwhile have a certain relationship with BMD.