Progress of microRNAs and B-cell receptor signaling pathway in chronic lymphocytic leukemia / 白血病·淋巴瘤
Journal of Leukemia & Lymphoma
;
(12): 432-436, 2017.
Artículo
en Chino
| WPRIM
| ID: wpr-616318
ABSTRACT
Many studies have confirmed that dysregulation of microRNAs (miRNAs) expression can cause disruption of the hematopoietic system and contribute to leukemogenesis by regulating the expression of some oncogenes and anti-oncogenes. Chronic lymphocytic leukemia (CLL) is a malignant proliferative disease of B lymphocytes with significant heterogeneity in the incidence of individuals, disease progression, treatment response and clinical prognosis. The increasing studies have shown that the mutation or abnormal expression of miRNAs is closely related to CLL occurrence, progression, prognosis and curative efficacy. Certain miRNAs are involved in the intricate interplay with B-cell receptor (BCR) signaling pathway. The review discusses the latest progress of miRNAs expression in BCR signaling pathway and CLL onset and progression.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
Journal of Leukemia & Lymphoma
Año:
2017
Tipo del documento:
Artículo
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