Effect of cumin total flavonoids on experimental gastric ulcer and its mechanism / 中国病理生理杂志

ABSTRACT

AIM: To discuss the effects of cumin total flavonoids on experimental gastric ulcer and the mechanisms.METHODS: Three rat gastric ulcer models induced by pylorus ligation, ethanol or reserpine were selected.Based on these models, the gastric juice, pH value, ulcer index and suppressive rate were recorded to determine the inhibitory effects of cumin flavonoids on rat gastric ulcers.In addition, the concentrations of gastrin (GAS), prostaglandin E2 (PGE2) and epidermal growth factor (EGF) were detected to further uncover the mechanisms of these effects.RESULTS: Cumin flavonoids exhibited significant anti-gastric ulcer effects on the three models.Low-dose treatment group (P<0.01) demonstrated higher inhibitory effects than high-dose group (P<0.01), and both low-and high-dose groups had lower effects than cimetidine treatment.Furthermore, cumin flavonoids were able to profoundly decrease the amount of gastric juice, free acidity, total acidity and output of total acid, and enhance the expression of PGE2 and EGF, but down-regulate the level of GAS in rat serum in a dose-dependent manner.CONCLUSION: Cumin flavonoids might inhibit experimental gastric ulcers by affecting and regulating the gastric juice, PEG2, EGF and GAS.