Lipopolysaccharide-binding protein plasma levels as a biomarker of obesity-related insulin resistance in adolescents / 소아과
Korean Journal of Pediatrics
; : 231-238, 2016.
Article
en En
| WPRIM
| ID: wpr-61662
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WPRO
ABSTRACT
PURPOSE: Lipopolysaccharide-binding protein (LBP) is a 65-kDa acute phase protein, derived from the liver, which is present in high concentrations in plasma. Data regarding the association between circulating plasma LBP levels and obesity-related biomarkers in the pediatric population are scarce. We aimed to determine whether there was a difference in plasma LBP levels between overweight/obese and normal-weight adolescents and to assess the correlation of circulating LBP levels with anthropometric measures and obesity-related biomarkers, including insulin resistance, liver enzyme levels, and lipid profiles. METHODS: The study included 87 adolescents aged 12-13 years; 44 were overweight/obese and 43 were of normal-weight. We assessed anthropometric and laboratory measures, including body mass index (BMI), blood pressure, insulin resistance, liver enzyme levels, and lipid profiles. Plasma LBP levels were measured using an enzyme-linked immunosorbent assay. RESULTS: The mean age of the participants was 12.9±0.3 years. Circulating plasma LBP levels were significantly increased in overweight/obese participants compared with those in normal-weight participants (7.8±1.9 µg/mL vs. 6.0±1.6 µg/mL, P<0.001). LBP levels were significantly and positively associated with BMI, systolic blood pressure, aspartate aminotransferase, alanine aminotransferase, total cholesterol, low density lipoprotein-cholesterol, fasting glucose and insulin, and insulin resistance as indicated by the homeostatic model assessment of insulin resistance (HOMA-IR) (all P<0.05). In multivariate linear regression analysis, BMI and HOMA-IR were independently and positively associated with plasma LBP levels. CONCLUSION: LBP is an inflammatory biomarker associated with BMI and obesity-related insulin resistance in adolescents. The positive correlation between these parameters suggests a potentially relevant pathophysiological mechanism linking LBP to obesity-related insulin resistance in adolescents.
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Índice:
WPRIM
Asunto principal:
Plasma
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Aspartato Aminotransferasas
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Presión Sanguínea
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Resistencia a la Insulina
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Proteínas de Fase Aguda
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Ensayo de Inmunoadsorción Enzimática
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Biomarcadores
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Índice de Masa Corporal
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Modelos Lineales
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Colesterol
Límite:
Adolescent
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Humans
Idioma:
En
Revista:
Korean Journal of Pediatrics
Año:
2016
Tipo del documento:
Article