Lipopolysaccharide-binding protein plasma levels as a biomarker of obesity-related insulin resistance in adolescents / 소아과
Korean Journal of Pediatrics
;
: 231-238, 2016.
Artículo
en Inglés
| WPRIM
| ID: wpr-61662
ABSTRACT
PURPOSE:
Lipopolysaccharide-binding protein (LBP) is a 65-kDa acute phase protein, derived from the liver, which is present in high concentrations in plasma. Data regarding the association between circulating plasma LBP levels and obesity-related biomarkers in the pediatric population are scarce. We aimed to determine whether there was a difference in plasma LBP levels between overweight/obese and normal-weight adolescents and to assess the correlation of circulating LBP levels with anthropometric measures and obesity-related biomarkers, including insulin resistance, liver enzyme levels, and lipid profiles.METHODS:
The study included 87 adolescents aged 12-13 years; 44 were overweight/obese and 43 were of normal-weight. We assessed anthropometric and laboratory measures, including body mass index (BMI), blood pressure, insulin resistance, liver enzyme levels, and lipid profiles. Plasma LBP levels were measured using an enzyme-linked immunosorbent assay.RESULTS:
The mean age of the participants was 12.9±0.3 years. Circulating plasma LBP levels were significantly increased in overweight/obese participants compared with those in normal-weight participants (7.8±1.9 µg/mL vs. 6.0±1.6 µg/mL, P<0.001). LBP levels were significantly and positively associated with BMI, systolic blood pressure, aspartate aminotransferase, alanine aminotransferase, total cholesterol, low density lipoprotein-cholesterol, fasting glucose and insulin, and insulin resistance as indicated by the homeostatic model assessment of insulin resistance (HOMA-IR) (all P<0.05). In multivariate linear regression analysis, BMI and HOMA-IR were independently and positively associated with plasma LBP levels.CONCLUSION:
LBP is an inflammatory biomarker associated with BMI and obesity-related insulin resistance in adolescents. The positive correlation between these parameters suggests a potentially relevant pathophysiological mechanism linking LBP to obesity-related insulin resistance in adolescents.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Plasma
/
Aspartato Aminotransferasas
/
Presión Sanguínea
/
Resistencia a la Insulina
/
Proteínas de Fase Aguda
/
Ensayo de Inmunoadsorción Enzimática
/
Biomarcadores
/
Índice de Masa Corporal
/
Modelos Lineales
/
Colesterol
Límite:
Adolescente
/
Humanos
Idioma:
Inglés
Revista:
Korean Journal of Pediatrics
Año:
2016
Tipo del documento:
Artículo
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