Value of five tumor markers in the diagnosis of lung cancer / 国际检验医学杂志

ABSTRACT

Objective To analyze the value of carbohydrate antigen(CA)153,CA125,neuron specific enolization enzyme(NSE) and carcinoembryonic antigen(CEA),cytokeratin(CYFRA)21-1 in the diagnosis of lung cancer.Methods From October 2014 to April 2016,60 patients were selected into lung cancer group,60 patients were selected into lung cancer group,60 healthy persons recruited into control group,blood specimens from all subjects received chemiluminescence immunoassay detection and analyzed.Results Five tumor markers for lung cancer detection had certain difference in sensitivity and specificity,the specific of NSE and CA153,the sensitivity of CEA and CYFRA21-1 in 5 tumor markers were the highest.The combination of 5 tumor markers could make the diagnosis of lung cancer more accurate,the differences of the specific and sensitivity between the combined detection and single detection were significant (P<0.05).Conclusion The combination detection of these five tumor markers could improve the diagnosis ability in patients with lung cancer.