Clinical observation of phentolamine in the treatment of infantile pneumonia complicated with heart failure and improvement of pulmonary rales / 中国基层医药

ABSTRACT

Objective To investigate the clinical effect of phentolamine in the treatment of heart failure in children with pneumonia and its effect on improvement of pulmonary rale.Methods 100 children with infantile pneumonia complicated with heart failure who admitted in our hospital were selected as the research subjects.According to the order of admission,the patients were divided into two groups.The control group was given routine treatment,patients in the observation group were given phentolamine on the basis of routine treatment.The treatment efficacy,symptoms relief time,hospitalization time,heart ultrasound index were compared between the two groups.ResultsThe effective rate of the observation group was 96.00％,which was significantly higher than 76.00％ of the control group (χ2=16.611,P=0.000).The pulmonary rales,wheezing disappearance time,hospitalization time of the observation group were (54.32±10.04)h,(87.32±11.23)h,and (7.71±1.23)d,respectively,which of the control group were (113.82±43.42)h,(158.49±45.82)h and (12.05±3.92)d,and there were statistically significant differences between the two groups (t=18.703,P=0.000;t=16.647,P=0.000;t=10.156,P=0.000).The E/A of the observation group was higher than that of the control group (t=2.890,P=0.000),and EF was lower than that of the control group (t=4.779,P=0.000).CK-Mb of the observation group was lower than the control group (t=2.045,P=0.013).The incidence rate of adverse reactions of the observation group was 2.00％,which of the control group was 4.00％,there was no significant difference between the two groups(χ2=0.687,P=0.407).ConclusionPhentolamine in the treatment of patients with infantile pneumonia complicated with heart failure,can reduce pulmonary rales,relieve clinical symptoms,shorten the hospitalization time,improve the treatment efficacy,and has less adverse reaction,high safety.