Analysis of clinicopathological characteristics and prognosis in 101 patients with pancreatic neuroendocrine neoplasms / 中国基层医药

ABSTRACT

Objective The aim of our study was to describe the clinicopathological characteristics and to evaluate the prognostic factors of postoperative PNENs.Methods The clinicopathological data of 101 postoperative PNENs patients were collected and analyzed retrospectively.We analyzed the clinicopathological characteristics and prognostic factors.The survival analysis was conducted by Kaplan-Meier method and survival analysis was performed by Cox model.Results 101 patients with PNENs were enrolled,including 46.5％ male(n=47) and 53.5％ female(n=54),the median age was 51 years old (ranged 19-80).94 patients(93.1％) with neuroendocrine tumors(NETs),7 patients(6.9％) with neuroendocrine carcinomas(NECs).The mean size of tumor was 3.3 cm(ranged 0.5-15).Immunohistochemistry staining positive rates for chromogranin A (CgA) and synaptophysin (Syn) were 89.0％ and 98.0％ respectively.Patients were 66 cases (65.3％),23 cases (22.8％) and 12 cases (11.9％) in TNM stage I,II and IV respectively.34 cases(33.7％) were F-PNENs,and 67 cases(66.3％) were NF-PNENs.Our study demonstrated that there were statistically significant differences between F-PNENs and NF-PNENs in stage,grade,neural and vascular invasion,CgA positive rate(χ2=10.372,18.162,9.699,5.547,4.043,P＜0.05).Meanwhile,significant differences were found between NETs and NECs in stage,neural and vascular invasion,CgA positive rate(χ2=11.642,5.254,14.458,5.254,P＜0.05).PNENs had better prognosis,with 5-year survival rate of 84.3％.The independent prognostic factor for survival was grade.Conclusion PNENs are a family of tumors with diversity clinical presentation and prognosis.Surgery is the main treatment method,grade of PNENs is the independent prognostic factor.