c-fos modulates p16/CyclinD1 signaling pathways and promotes the proliferation and migration of oral squamous cell carcinoma / 实用口腔医学杂志
Journal of Practical Stomatology
; (6): 100-104, 2017.
Article
en Zh
| WPRIM
| ID: wpr-619232
Biblioteca responsable:
WPRO
ABSTRACT
Objective:To investigate the effect of c-fos on the proliferation and migration of oral squamous cell carcinoma and potential mechansism.Methods:The expression of c-fos,CyclinD1 and p16 in 60 oral squamous cell carcinoma samples and 60 oral mucosa tissue samples was examined by immunohistochemistry.HN6 and SCC9 cells were respectively transfected with siRNA-c-fos and siRNA-scramble,then were respectively divided into control group,siRNA-scramble group and siRNA-c-fos group.The mRNA and protein expressions of CyclinD1 and p16 were decteted,meanwhile cell proliferation and migration were tested.Results:Compared with the oral mucosa tissue samples,the expressions of CyclinD1 and c-fos were increased in the carcinoma samples,while the expression of p16 was reduced.Compared with control group,the expressions of CyclinD1 in siRNA-c-fos group were significantly reduced,while p16 enpression was increased,with the inhibition of cell proliferation and migration.Conclusion:c-fos may regulate pl6/CyclinD1 signaling pathways and promote the proliferation and migration of oral squamous cell carcinoma.
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WPRIM
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Zh
Revista:
Journal of Practical Stomatology
Año:
2017
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Article