Recent advances in research of gut microbiota and Alzheimer's disease / 中国药理学通报

ABSTRACT

Alzheimer's disease (AD) is a neurodegenerative disease of the central nervous system, and its pathogenesis is very complex.As a large number of microorganisms in the human digestive tract, intestinal flora is the important environmental factor in the process of human health and disease.The brain-gut axis is a bidirectional information regulation system which connects the brain and the gastrointestinal.The intestinal microbes can participate in the brain-gut axis activity, and influence the brain function and some related behaviors under physiological and pathological conditions.Recent studies have shown that intestinal microorganisms are closely related to AD, and they interact with each other through immune, endocrine and vagal pathways to form complex networks.Many reports have shown that probiotics or traditional Chinese medicine can regulate the state of intestinal microflora and improve AD symptoms.Therefore, in order to provide a new research idea and method for the clinical prevention and treatment of AD, it is necessary to further study the interaction between intestinal microbes, traditional Chinese medicine and AD.