Observation on the effect of fasudil hydrochloride combined with mannitol on the treatment of the patients with brain edema after brain tumor operation / 中国生化药物杂志

ABSTRACT

Objective To investigate the clinical efficacy of fasudil hydrochloride combined with mannitol on the treatment of the patients with cerebral edema after brain tumor operation. Methods In this study, 76 patients with brain edema after brain tumor operation from May 2015 to October 2016 were were divided into the control group and the observation group according to different administration, 38 cases in each group.The control group was treated with mannitol and the observation group was treated with fasudil hydrochloride combined with mannitol. Comparison of the two groups of treatment efficiency, neurological score, brain edema area and adverse reactions. Results The total effective rate 97.37% in the observation group was significantly higher than 78.95% in the control group(P<0.05).The level of neurological function was (10.05 ± 1.78) points and brain edema was (21.06±2.51) cm3in the observation group which were significantly lower than those in the control group (13.36±2.02), (27.09 ±3.75) cm3(P<0.05). The incidence of adverse events (2.63%) in the observation group was not significantly different from that in the control group (5.26%). Conclusion The effect of fasudil hydrochloride combined with mannitol on cerebral edema after brain tumor operation is more remarkable than that of simple treatment, and the brain edema area and neurological function score of patients are reduced. Therefore, the therapeutic regimen can be the recommended for clinical application..