Pathophysiology of Craniocerebral Trauma

ABSTRACT

In the past decade, major advances have been made in defining and, to some extent, quantifying the types of brain damage that occur in non-missile head injury, and in identifying their pathogenesis, using biological models of head injury. There have been various approaches to the classification of brain damage and we have tended to emphasize the existence of primary and secondary damage from impairment of cerebral blood flow and brain metabolism, which helps in the identification of at least potentially preventable complications.