Thyroglobulin and thyroglobulin antibody in differential diagnosis between differentiated thyroid carcinoma and nodular goiter / 中华内分泌外科杂志

ABSTRACT

Objective To investigate the clinical significance of thyroglobulin(TG) and thyroglobulin antibody (TGAb) in differential diagnosis between nodular goiter and differentiated thyroid carcinoma(DTC).Methods From Jan.2006 to Jan.2007,180 cases of thyroid carcinoma were included in group A(male45,average age47 ; female135,average age43)and 150 cases of nodular goiter were included in group B (Male55,average age 43 ; female95,average age41).All the cases came from the General Department of Chengde Central Hospital.Group C (the control group) included 120 cases (male40,average age38 ; female80,average age44).All patients underwent thyroids ultrasound,thyroid function detection and CT.Results The positive rate of TG and TGAb was 40.0％ and 43.3％ in group A,which were obviously higher than those in group B (7.33％,9.33％)and group C(4.17％,7.50％).The difference had statistical significance(P ＜0.05).However,there was no statistical difference between group B and group C (P ＞ 0.05).Conclusion The measurement of TG and TGAb has clinical significance in differential diagnosis between DTC and nodular goiter.