Relationship between Therapeutic Response and Plasma HVA/5-HIAA Ratio in Newly Admitted Schizophrenia / 대한정신약물학회지
Korean Journal of Psychopharmacology
;
: 101-106, 1997.
Artículo
en Coreano
| WPRIM
| ID: wpr-62704
ABSTRACT
Twenty newly admitted acute schizophrenic patients were treated with haloperidol for 6 weeks. HVA and 5-HIAA were sampled at baseline, 3days after initial neuroleptic dose, and after 1, 2, 3, 4, 6 weeks of treatment. Nine patients were classified as responders in this prospective haloperidol treatment trial. They had a score of change in the BPRS total scores of 25% or greater. Eleven patients were classified as nonresponders, based on a score of changes in the BPRS total scores of less than 25%. 1) There was no significant difference in plasma HVA/5-HIAA ratio between responder and non-responder before and after haloperidol treatment. 2) There was no significant correlations between plasma HVA/5-HIAA ratio and BPRS total scores. This study could not support the hypothesis that neuroleptic treatment would be effective by changing dopamine and serotonin function and/or by altering their interaction.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Plasma
/
Esquizofrenia
/
Dopamina
/
Serotonina
/
Estudios Prospectivos
/
Haloperidol
/
Ácido Hidroxiindolacético
Tipo de estudio:
Estudio observacional
Límite:
Humanos
Idioma:
Coreano
Revista:
Korean Journal of Psychopharmacology
Año:
1997
Tipo del documento:
Artículo
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