Planimetric and Biomechanical Study of Local Effect of Pulegone on Full Thickness Wound Healing in Rat
Malaysian Journal of Medical Sciences
;
: 52-61, 2017.
Artículo
en Inglés
| WPRIM
| ID: wpr-629070
ABSTRACT
Background:
Pulegone as principal component of essential oil, reported to have antibacterial, antioxidant and anti-inflammatory properties. The present study was aimed to evaluate wound healing activity of pulegone in a rat model.Method:
Forty rats were used for excisional and incisional wound healing models. For each model twenty male white Wistar rats were randomly divided into five groups (n = 4) of control (CG), Sham surgery, E1, E2 and E3. Wound size, hydroxyproline content of wound and biomechanical testing were assessed.Result:
In E2 animals, the wound size was reduced earlier than in E1 and E2 groups (P = 0.035). However, time had significant effect on wound contraction of all wounds. Hydroxyproline contents in the groups CG, sham surgery, E1, E2 and E3 were found to be 51.25 ± 3.40, 58.41 ± 4.62, 68.59 ± 3.53, 86.32 ± 3.18, and 74.26 ± 4.73 mg g-1, respectively. Hydroxyproline contents were increased significantly in E2 compared to E1 and E3 which implied more collagen deposition compared to other experimental groups (P = 0.001). The biomechanical indices, maximum stored energy, stiffness, ultimate strength and yield strength obtained for E2 group were significantly higher than those obtained for E1 and E2 groups (P = 0.002).Conclusion:
The pulegone showed a reproducible wound healing potential in rats.
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Índice:
WPRIM (Pacífico Occidental)
Idioma:
Inglés
Revista:
Malaysian Journal of Medical Sciences
Año:
2017
Tipo del documento:
Artículo
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