In vivo chromosome aberration test for hydroxyapetite in mice
The Medical Journal of Malaysia
;
: 115-116, 2004.
Artículo
en Malayalam
| WPRIM
| ID: wpr-629941
ABSTRACT
This study evaluates the cytotoxic and mutagenic effect of synthetic hydroxyapatite granules (source School of Material and Mineral Resources Engineering, Universiti Sains Malaysia) in the bone marrow cells of mice. Mice are exposed to synthetic hydroxyapatite granules, the bone marrow cells are collected and observed for chromosome aberrations. No chromosome aberrations were noticed in the animals exposed to distilled water (negative control) and to the test substance, synthetic hydroxyapatite granules (treatment) groups. Chromosome aberrations were observed in the animals exposed to Mitomycin C (positive control group). There was no indication of cytotoxicity due to synthetic hydroxyapatite granules in the animals as revealed by the mitotic index. Hence, synthetic hydroxyapatite granules are considered non-mutagenic under the prevailing test conditions.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Células de la Médula Ósea
/
Aberraciones Cromosómicas
/
Durapatita
/
Sustitutos de Huesos
/
Pruebas de Mutagenicidad
Idioma:
Malayalam
Revista:
The Medical Journal of Malaysia
Año:
2004
Tipo del documento:
Artículo
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