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Tissue-engineered bone via seeding bone marrow stem cell derived osteoblasts into coral: a rat model
The Medical Journal of Malaysia ; : 200-201, 2004.
Artículo en Malayalam | WPRIM | ID: wpr-629963
ABSTRACT
In the present study, natural coral of porites species was used as scaffold combined with in vitro expanded bone marrow stem cell derived osteoblasts (BMSC-DO), to develop a tissue-engineered bone graft in a rat model. Coral was molded into the shape of rat mandible seeded with 5x10(6) /ml BMSC-DO subsequently implanted subcutaneously in the back of 5 week Sprague dawely rats for 3 months. Coral alone was implanted as a control. The implants were harvest and processed for gross inspection and histological observations. The results showed that newly bone grafts were successfully formed coral seeded with cells group showed smooth highly vascularized like bone tissue. Histological sections revealed mature bone formation and lots of blood vessel, the bone formation occurred in the manner resemble intramembraneous bone formation. This study demonstrates that coral can be use as a suitable scaffold material for delivering bone marrow mesenchymal stem cells in tissue engineering.
Asunto(s)
Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Técnicas de Cultivo de Órganos / Osteoblastos / Biodegradación Ambiental / Carbonato de Calcio / Células de la Médula Ósea / Microscopía Electrónica de Rastreo / Trasplante Óseo / Ingeniería de Tejidos / Antozoos / Células Madre Mesenquimatosas Idioma: Malayalam Revista: The Medical Journal of Malaysia Año: 2004 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Técnicas de Cultivo de Órganos / Osteoblastos / Biodegradación Ambiental / Carbonato de Calcio / Células de la Médula Ósea / Microscopía Electrónica de Rastreo / Trasplante Óseo / Ingeniería de Tejidos / Antozoos / Células Madre Mesenquimatosas Idioma: Malayalam Revista: The Medical Journal of Malaysia Año: 2004 Tipo del documento: Artículo