Synthesis of precursor of anti-inflammatory agents by using highly reactive zinc
The Medical Journal of Malaysia
;
: 210-211, 2004.
Artículo
en Malayalam
| WPRIM
| ID: wpr-629965
ABSTRACT
Highly reactive zinc metal was prepared by electrolysis of a N,N-dimethylformamide (DMF) solution containing naphthalene and a supporting electrolyte in a one-compartment cell fitted with a platinum cathode and a zinc anode. This highly reactive electrogenerated zinc (EGZn/Naph) was used for transformation of ethyl 2-bromoacrylate into the corresponding organozinc compound, which can not be achieved by the use of usual zinc metals. Reaction of the organozinc compounds thus prepared with various aryl halides in the presence of 5 mol% of palladium catalyst gave the corresponding cross-coupling products in high yields. These cross-coupling reactions were successfully applied to a synthesis of the precursor of anti-inflammatory agents such as ibuprofen, naproxen, cicloprofen and suprofen.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Propionatos
/
Zinc
/
Profármacos
/
Catálisis
/
Suprofeno
/
Antiinflamatorios no Esteroideos
/
Ibuprofeno
/
Naproxeno
/
Electrólisis
/
Naftalenos
Idioma:
Malayalam
Revista:
The Medical Journal of Malaysia
Año:
2004
Tipo del documento:
Artículo
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