Immune response of BALB/c mice against an experimental vaccine of Alum precipitated autoclaved Leishmania major (Alum-ALM) mixed with BCG or Mycobacterium vaccae
Tropical Biomedicine
;
: 89-102, 2010.
Artículo
en Inglés
| WPRIM
| ID: wpr-630019
ABSTRACT
Immune response in BALB/c mice immunized 3 times with different doses (50 mug or 200 mug of protein) of Alum precipitated autoclaved Leishmania major (Alum-ALM) mixed with either BCG (1 x10(7); CFU) or different doses of killed Mycobacterium vaccae (1 x10(6), 1 x10(7)) was assessed. Mice immunized with low dose of Alum-ALM mixed with either BCG or low M. vaccae showed a significantly higher IFN-gamma production and a lower IL-4 level and a significantly lower parasite burden compared to the control PBS injected group. It seems that immunization with a low dose of Alum-ALM mixed with an adjuvant induces a Th1 type of immune response in susceptible BALB/c mice.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Idioma:
Inglés
Revista:
Tropical Biomedicine
Año:
2010
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS