A Review of Colorectal Cancer Research in Malaysia

ABSTRACT

105 articles related to colorectal cancer(CRC) were found in a search through a database dedicated to indexing all original data relevant to medicine published in Malaysia between the years 2000-2013. 56 articles were selected and reviewed on the basis of clinical relevance and future research implications. Research into the genetic basis for colorectal cancer included studies in germline mutations of known syndromes as well as polymorphisms that conferred individuals a higher odds ratio for developing CRC. Several studies also documented the variety of somatic mutations seen in cases of sporadic CRC in Malaysia. Studies into the knowledge and attitudes of Malaysians regarding CRC revealed poor appreciation of the common symptoms, risk factors and available measures for its early detection. This may explain the observed facts that more Malaysians present with late stage CRC than seen in developed countries. The small amount of data recorded concerning the outcome of treatment also suggests overall survival of Malaysian CRC patients for comparable stage of CRC is lower than achieved in developed countries. KEY WORDS Colorectal cancer; Malaysia; Review; genetics; screening; diagnosis; staging; treatment; outcome: