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Topical Photodynamic Therapy with Methyl-aminolevulinic Acid for the Treatment of Actinic Keratosis / 대한피부과학회지
Korean Journal of Dermatology ; : 837-843, 2010.
Artículo en Coreano | WPRIM | ID: wpr-63110
ABSTRACT

BACKGROUND:

Photodynamic therapy (PDT) is a treatment modality involving the use of a photosensitizer, oxygen and a light source to induce selective targeted cell death. It is used for various skin conditions, including actinic keratosis (AK). Both 5-aminolevulinic acid and methyl aminolevulinic acid (MAL) are currently available as photosensitizers. Although there are several studies on the treatment of AK using 5-aminolevulinic acid-PDT in Korea, there are few studies on using MAL-PDT for the treatment of AK.

OBJECTIVE:

The purpose of this study is to evaluate the efficacy and safety of MAL-PDT for the treatment of AK.

METHODS:

We performed a retrospective study and reviewed 64 AK lesions from 28 patients who were treated by MAL-PDT between January 2008 and April 2010. The data was collected through the medical records, the clinical photographs and the biopsy specimens.

RESULTS:

The patients were treated with either a single treatment or double treatments 1 week apart. The treatment results were assessed after 12 weeks. Overall, complete remission was achieved in 42/64 lesions (65.6%). Although a single treatment was effective for thin lesions, the complete response rates were significantly lower for the moderately thick and severely thick lesions (100% vs 71.3% vs 22.2%, respectively). Repeated treatment tended to improve the complete response rate of the severely thick lesions. A favorable cosmetic outcome was achieved and only tolerable local side effects were reported after MAL-PDT. The patients were followed up for an average period of 6 months and 4 lesions recurred.

CONCLUSION:

MAL-PDT is an effective and well-tolerated treatment option for thin and moderately thick AK. However, further study is required for determining the optimal regimen for thicker lesions and the long-term treatment results of MAL-PDT.
Asunto(s)

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Oxígeno / Fotoquimioterapia / Piel / Biopsia / Registros Médicos / Estudios Retrospectivos / Actinas / Muerte Celular / Fármacos Fotosensibilizantes / Cosméticos Tipo de estudio: Estudio observacional Límite: Humanos País/Región como asunto: Asia Idioma: Coreano Revista: Korean Journal of Dermatology Año: 2010 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Oxígeno / Fotoquimioterapia / Piel / Biopsia / Registros Médicos / Estudios Retrospectivos / Actinas / Muerte Celular / Fármacos Fotosensibilizantes / Cosméticos Tipo de estudio: Estudio observacional Límite: Humanos País/Región como asunto: Asia Idioma: Coreano Revista: Korean Journal of Dermatology Año: 2010 Tipo del documento: Artículo