Mivacurium for rapid tracheal intubation: the timing principle
Philippine Journal of Anesthesiology
;
: 1-6, 2000.
Artículo
en Inglés
| WPRIM
| ID: wpr-632093
ABSTRACT
BACKGROUND:
The timing principle entails administration of a single bolus of non-depolarizing muscle relaxant, followed by an induction agent at the onset of neuromuscular blockade. Three different mivacurium dose regimens were compared to determine its safety and efficacy for rapid tracheal intubation in FilipinosMETHODS:
Sixty ASA I or II patients, 20-65 years old, surgery requiring orotracheal intubation were randomly allocated into three groups. Group I received 0.20 mg/kg, Group II 0.25 mg/kg, and Group III 0.30 mg/kg mivacurium over for twenty seconds. At the onset of 3-5 percent change in TOF, considered as the onset time, anesthesia was induced with thiopental at 5 mg/kg; laryngoscopy was accomplished at 95 percent neuromuscular blockade. Intubating conditions were assessed according to the Copenhagen Consensus Conference CCC rating scaleRESULTS:
The mean onset times for Groups I to III were 64.5 +/- 16.6 seconds, 47.5 +/- 10.8 seconds and 21.5 +/- 7.96 respectively, while the time to 95 percent blocks were 85.5 +/- 30.7 seconds, 57.8 +/- 9.8 seconds, and 35.0 +/- 9.9 seconds. Intubating conditions were either good or excellent in all patients. All patients were satisfied with the manner of induction of anesthesiaCONCLUSION:
Mivacurium at a dose of 0.3 mg/kg using the timing principle consistently provided good to excellent intubating conditions, 35-45 seconds after induction of anesthesia and is an acceptable alternative to succinylcholine for rapid tracheal intubation. (Author)
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Succinilcolina
/
Bloqueo Neuromuscular
/
Mivacurio
/
Hemodinámica
/
Anestesia
/
Laringoscopía
Límite:
Adolescente
/
Adulto
/
Anciano
/
Humanos
Idioma:
Inglés
Revista:
Philippine Journal of Anesthesiology
Año:
2000
Tipo del documento:
Artículo
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