The unique phenomenology of sex-linked dystonia parkinsonism (XDP, DYT3, "Lubag")
Philippine Journal of Neurology
;
: 63-71, 2012.
Artículo
en Inglés
| WPRIM
| ID: wpr-633151
ABSTRACT
Sex-linked dystonia parkinsonism (XDP, DYT3, "Lubag") is an adult-onset, progressive, debilitating movement disorder first described in Filipino males from Panay Island in 1975. XDP manifests predominantly as torsion dystonia, later combined with or sometimes replaced with parkinsonism. Within the Island of Panay, the preva-lence rate is highest in the province of Capiz, where 14000 men suffer from the disorder. There is a high degree of penetrance and generalization. While women often serve as carriers, XDP is not limited to men. An updated XDP Philippine registry (as of January 2010) has identified 505 cases, with 500 males and 5 females. While some report that females may carry a milder form of the disorder, in our experience, both sexes generally follow a similar progressive clinical course.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Penetrancia
/
Trastornos Parkinsonianos
/
Trastornos Distónicos
/
Enfermedades Genéticas Ligadas al Cromosoma X
/
Distonía
/
Distonía Muscular Deformante
/
Islas
Tipo de estudio:
Investigación cualitativa
Límite:
Adulto
/
Anciano
/
Femenino
/
Humanos
/
Masculino
Idioma:
Inglés
Revista:
Philippine Journal of Neurology
Año:
2012
Tipo del documento:
Artículo
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