Study on the pharmacokinetics and relative bioavailability of irbesartan capsules in healthy volunteers / 华中科技大学学报(医学)(英德文版)
Journal of Huazhong University of Science and Technology (Medical Sciences)
;
(6): 14-6, 2002.
Artículo
en Inglés
| WPRIM
| ID: wpr-634051
ABSTRACT
The pharmacokinetics and relative bioavailability were studied in 18 healthy volunteers. A single oral dose of 150 mg irbesartan capsule (test) or tablet (reference) was given to each volunteer according to a randomized 2-way crossover study. The concentrations in plasma were determined by HPLC-UV method. The main parameters of irbesartan capsules were Cmax 1.502 +/- 0.295 micrograms/ml, tmax 1.44 +/- 0.34 h, t 1/2 20.21 +/- 14.71 h, AUC0-t 11.087 +/- 3.443 micrograms/ml-1.h. The relative bioavailability of capsule to tablet was (101.4 +/- 28.9)%. The results of statistical analysis showed that two formulations were bioequivalent.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Comprimidos
/
Tetrazoles
/
Compuestos de Bifenilo
/
Cápsulas
/
Receptores de Angiotensina
/
Disponibilidad Biológica
/
Estudios Cruzados
Tipo de estudio:
Ensayo Clínico Controlado
Idioma:
Inglés
Revista:
Journal of Huazhong University of Science and Technology (Medical Sciences)
Año:
2002
Tipo del documento:
Artículo
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