Your browser doesn't support javascript.
loading
Effects of ligustrazine on the contraction of isolated rabbit corpus cavernosum strips / 华中科技大学学报(医学)(英德文版)
Journal of Huazhong University of Science and Technology (Medical Sciences) ; (6): 565-7, 2005.
Artículo en Inglés | WPRIM | ID: wpr-634825
ABSTRACT
To investigate the role of ligustrazine on relaxation of the isolated rabbit corpus cavernosum tissue in vitro, the effects of ligustrazine on the corpus cavernosum were observed by using experimental method of smooth muscle strips. Concentration-responses to phenylephine (PE) and KCl were recorded. The results showed that ligustrazine concentration-dependently depressed the contraction response of smooth muscle strips induced by PE. The maximum percentage relaxation of cavernosal strips by ligustrazine was 74.1% +/- 6.2% (compared with control 21.9% +/- 5.6%, P < 0.01). Ligustrazine concentration-dependently reduced the amplitude of the contraction induced by cumulative doses of PE or KCl, shifted the cumulative concentration response curves of PE and KCI to the right and depressed their maximal responses. It was concluded that ligustrazine could significantly relax the cavernosal muscle contraction induced by PE in vitro. The results suggested that ligustrazine inhibited calcium ion influx.
Asunto(s)
Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Pene / Fenilefrina / Cloruro de Potasio / Pirazinas / Canales de Calcio / Contracción Muscular / Relajación Muscular / Músculo Liso Idioma: Inglés Revista: Journal of Huazhong University of Science and Technology (Medical Sciences) Año: 2005 Tipo del documento: Artículo

Similares

MEDLINE

...
LILACS

LIS

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Pene / Fenilefrina / Cloruro de Potasio / Pirazinas / Canales de Calcio / Contracción Muscular / Relajación Muscular / Músculo Liso Idioma: Inglés Revista: Journal of Huazhong University of Science and Technology (Medical Sciences) Año: 2005 Tipo del documento: Artículo