Study on influence of some additifs on stability of eye drops with vitamine B5

ABSTRACT

The effect of buffer system, adjustment substance pH, pH of solution, antioxygen and antiseptic on the stability of eye drop solution with vitamin B5 was studied. The result: at pH 5,5, buffer system of acetat, of citrat and of phosphat strictly influence to the stability of eye drop solution containing vitamin B5. This solution also sustained with antioxygen dinatri edetat 0,02%, combining with natri metabisulfid 0,1% -0,3% don’t make increase the stability of product. The antiseptic of benzalkonium clorid and chlorobutanol don’t influence to the stability of this solution. But benzalkonium clorid is appropriate than chlorobutanol because of it don’t absorb through PE plastic, the antiseptic efficacy increase with the presence of dinatri edetat and this make increase the bioavailability of drug