Neurological Manifestations of Acute Intermittent Porphyria
Journal of the Korean Neurological Association
;
: 475-478, 2002.
Artículo
en Coreano
| WPRIM
| ID: wpr-63545
ABSTRACT
BACKGROUND:
Acute intermittent porphyria (AIP) is an autosomal dominant disorder characterized by recurrent abdominal pain with neuropsychiatric symptoms and motor dominant polyneuropathy. The purpose of this study is to characterize neurological manifestations and clinical course of AIP in Korean.METHODS:
Medical records from 1984 to 2001 were reviewed retrospectively. There were 23 cases of laboratory confirmed AIP.RESULTS:
The clinical characteristics of AIP are the acute abdominal pain without fever or leukocytosis. Neuropsychiatric symptoms or polyneuropathy occurred in 13 cases (56.5%). Among the 13 cases, there were 4 cases with neuropsychiatric symptoms only, 3 with polyneuropathy only and 6 with both of them. Polyneuropathy was usually preceded by neuropsychiatric symptoms. Severe sensori-motor polyneuropathy with respiratory failure occurred in 4 cases, where one expired. Hyponatremia was seen in 14 cases (60.8%) and 7 of them had the neuropsychiatric symptoms.CONCLUSIONS:
The clinical characteristics of AIP include acute abdominal pain without leukocytosis or fever, and hyponateremia. The neuropsychiatric symptoms and peripheral neuropathy in AIP may occur by improper treatment for the acute abdominal pain, and can worsen by wrong treatment without clinical suspicion.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Polineuropatías
/
Insuficiencia Respiratoria
/
Convulsiones
/
Dolor Abdominal
/
Registros Médicos
/
Estudios Retrospectivos
/
Porfiria Intermitente Aguda
/
Enfermedades del Sistema Nervioso Periférico
/
Fiebre
/
Hiponatremia
Tipo de estudio:
Estudio observacional
Idioma:
Coreano
Revista:
Journal of the Korean Neurological Association
Año:
2002
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS