Correlations between the Left Ventricular Diastolic Function and Aortic Stiffness in Healthy Aged Subjects
Korean Circulation Journal
;
: 393-399, 2006.
Artículo
en Coreano
| WPRIM
| ID: wpr-63615
ABSTRACT
BACKGROUND AND OBJECTIVES:
Arterial stiffness and wave reflections increase with advancing age, and the systolic and pulse pressures are elevated. These changes in aortic stiffness and pulse wave velocity with aging may change the cardiac function. The diastolic function of the left ventricle declines with aging even in normal healthy subjects too. This investigation was designed to assess the correlations between the left ventricular diastolic function and arterial stiffness with using echocardiography including doppler tissue imaging (DTI) and an applanation tonometer. SUBJECTS ANDMETHODS:
The subjects were 100 healthy volunteers who had normal left ventricular systolic function and no major cardiovascular risk factors such as hypertension, hypercholesterolemia, diabetes, obesity and smoking. The left ventricular diastolic function was assessed with the mitral inflow indexes and DTI, and the pulmonary venous return was measured by echocardiography. The central aorta blood pressure, the augmentation index (AIx) and the pulse wave velocity (PWV) were evaluated by using an applanation tonometer (SphygmoCoR system).RESULTS:
With advancing age, the left mitral E/A ratio decreased (r=-.738, p<0.05) and the DTI early/late diastolic velocity (E'/A') ratio decreased (r=-.759, p<0.05), which showed a significant change of the left ventricular diastolic function. The Aix (r=.406, p<0.05) and PWV (r=.614, p<0.05) increased with aging. The PWV correlated significantly with the E/A ratio (r=-.593, p<0.05) and the E'/A' ratio (r=-.559, p<0.05).CONCLUSION:
This study showed that increases of the large conduit vessel stiffness with aging are associated with a decline of the left ventricular diastolic function in healthy subjects.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Aorta
/
Humo
/
Velocidad del Flujo Sanguíneo
/
Presión Sanguínea
/
Envejecimiento
/
Ecocardiografía
/
Fumar
/
Factores de Riesgo
/
Diástole
/
Aterosclerosis
Tipo de estudio:
Estudio de etiología
/
Factores de riesgo
Límite:
Humanos
Idioma:
Coreano
Revista:
Korean Circulation Journal
Año:
2006
Tipo del documento:
Artículo
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