Recent progress in the ubiquitination regulation of transforming growth factor-β/Smads signal transduction pathway in diabetic retinopathy / 中华实验眼科杂志

ABSTRACT

Diabetic retinopathy (DR) is one of the common and serious diabetic complications,with a complex nosogenesis.Studies have shown that transforming growth factor-β (TGF-β) participates in the occurrence and development of DR,and Smads protein is able to mediate and activate TGF-β/Smads signal transduction pathway and further involves in the pathogenesis of DR.Smurf is one of the ubiquitin ligases in ubiquitin-proteasome pathway,and it is clarified to regulate TGF-β/Smads signal transduction pathway degradation.At present,the study on the relationship between TGF-β/Smads pathway and DR has made great progress.The role of ubiquitin-proteasome pathway regulating TGF-β/Smads signal transduction pathway in DR is reviewed in this article.