Contrast-enhanced ultrasound imaging and quantitative parameters of fluorocarbon:compared with SonoVue / 中华医学超声杂志（电子版）

ABSTRACT

Objective To explore the difference of the contrast-enhanced ultrasound (CEUS) image and quantitative parameters between two different contrast agents Fluorocarbon and SonoVue. Methods The tumor model of colorectal carcinoma in nude mice was established by injecting CT26 cells into the subcutaneous space in hepatic area of 15 nude mice. CEUS was performed with Fluorocarbon and SonoVue on the 14th day after establishment. SonoLiver software was used to analyze the dynamic image quantitatively. The difference of the CEUS image and quantitative parameters between the two contrast agents was analyzed. Results Compared with normal liver parenchyma around the tumor, the tumor ultrasound contrast performance was fast forward and rewind with low enhancement. There was no signiifcant difference between the two kinds of microbubbles not only for CEUS image but also for quantitative parameters [maximum intensity (Imax)49.53%±24.38%vs 45.04%±17.03%, rise time (RT)11.68 s±3.07 s vs 13.76 s±2.92 s, time to peak (TTP)12.76 s±4.12 s vs 15.26 s±3.74 s, T1/250.57 s±28.32 s vs 48.75 s±9.85 s, Imax/TTP(V1)4.48±2.82 vs 3.18±1.49, (Imax-INT60)/(60-TTP)(V2)0.67±0.34 vs 0.60±0.20, AUC13032.78%±1343.12%vs 3258.77%±1369.84%, AUC211647.38%±6183.10%vs 10439.04%±4604.65%, AUC14680.17%±7469.85%vs 13697.81%±5831.99%, Rate of AUC1264.25±146.93 vs 222.24±92.16, Rate of AUC2241.67±119.97 vs 231.97±100.34, all P>0.05). No mouse was dead during the CEUS examination. Conclusion Fluorocarbon had similar CEUS imaging effect and quantitative information compared with SonoVue.