Research progress of SlRT1 as a target for the treatment of age - related retinal disease / 国际眼科杂志(Guoji Yanke Zazhi)
International Eye Science
;
(12): 233-237, 2015.
Artículo
en Chino
| WPRIM
| ID: wpr-637173
ABSTRACT
Silent information regulator protein 1 (SlRT1) is one of the sirtuins and belongs to histone deacetyase. lts activity depends on nicotinamide adenine dinucleotide ( NAD+) and is regulated by NAD+. Experimental and clinical studies have shown the neuro-protective effect of SlRT1 in the pathogenesis of age-related eye diseases. ln this review, the relationship between SlRT1 activator and apoptosis in the retinal cells were discussed. The review also points to SlRT1 as a potential therapeutic target for the clinical management of age-related retinal disease.
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Índice:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
International Eye Science
Año:
2015
Tipo del documento:
Artículo
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