HLA-A, B and DRB1 Genes Related with Susceptibility and Type of Hansen's Disease / 나학회지
Korean Leprosy Bulletin
;
: 67-78, 2000.
Artículo
en Coreano
| WPRIM
| ID: wpr-63794
ABSTRACT
To find out whether the susceptibility to Hansen's disease are associated with HLA genes, serological and nucleotide typing of HLA-A, B, and DRB1 alleles have been conducted in 301 Hansen's disease patients[190 Multibacillary cases(MB, LL/BL), 111 Paucibacillary cases(PB, TT/BT) confirmed at the time of diagnosis, almost of them were treated with Multidrug therapy] and 928 healthy controls from a population in Seoul and Northern area of Han River in Kyunggi Province, Korea. HLA-A30[relative risk(RR) 1.58, chi-square=4.89, P=0.04] was significantly associated with Hansen's disease. In contrast to HLA-B27(RR 0.20, chi-square=11.34, P=0.0002), which was negatively associated with Hansen's disease as a whole, in MB and PB separately, HLA-B52(RR 1.97, chi-square=6.89, P=0.002) and B46(RR 1.63, chi-square=4.84, P=0.04) were significantly increased in Hansen's disease. DRB1*02 was associated with MB(LL/BL)[RR 1.96, chi-square=13.47, P=0.0004] but not with PB(TT/BT). Further works about oligonuceotide typing of DQA,B, and DPB1 are ongoing. High resolution study to define DRB1*02 alleles will be performed.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Antígenos HLA-A
/
Ríos
/
Diagnóstico
/
Alelos
/
Seúl
/
Corea (Geográfico)
/
Lepra
Tipo de estudio:
Estudio diagnóstico
/
Estudio de etiología
País/Región como asunto:
Asia
Idioma:
Coreano
Revista:
Korean Leprosy Bulletin
Año:
2000
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS