Influence of Pulmonary Hypertension Induced by Left-to-Right Shunt on Pulmonary Collagen Remodeling / 实用儿科临床杂志
Journal of Applied Clinical Pediatrics
;
(24)2004.
Artículo
en Chino
| WPRIM
| ID: wpr-638636
ABSTRACT
Objective To establish a rat model of pulmonary hypertension induced by left-to-right shunt and explore the influence of high pulmonary blood flow on pulmonary vascular collagen remodeling.Methods Abdominal aorta and inferior vena cava shunting was produced in rats. Pulmonary artery meanpressure (PAMP) of each rat was measured by using a right cardiac catheterization.Pulmonary artery collagen Ⅰ and Ⅲ were detected using immunohistochemisty.Results After 11 weeks of shunting the Qp/Qs was 3.3∶1.0,indicating a large shunt. Pulmonary artery mean pressure was increased as compared with controls[(23.0?0.9) mm Hg vs (15.7? 1.1) mm Hg,P
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Índice:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
Journal of Applied Clinical Pediatrics
Año:
2004
Tipo del documento:
Artículo
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