Expressions of GATA-3 and Th2 Cytokines in Asthmatic Mice and Their Significances / 实用儿科临床杂志
Journal of Applied Clinical Pediatrics
; (24)1994.
Article
en Zh
| WPRIM
| ID: wpr-639098
Biblioteca responsable:
WPRO
ABSTRACT
Objective To investigate the expressions and significances of GATA-3 and Th2 cytokines in asthmatic mice.Methods Sixteen BALB/c mice were randomly divided into control group and asthmatic group.The pathological changes in trachial and pulmonary tissue were observed with HE staining method.The GATA-3 mRNA expression in pulmonary tissue was messured with reverse transcription polymerase chain reaction(RT-PCR).And the IL-5,IL-13 proteins in pulmonary tissue were detected with enzyme linked immunosorbent assay(ELISA).Results HE staining showed infiltration of a great deal of inflammatory cells around the bronchial wall in asthmatic group,while there was no obvious infiltration in control group;Compared with control group,the expressions of GATA-3 mRNA and IL-5,IL-13 protein in pulmonary tissue increased significantly(Pa
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Índice:
WPRIM
Idioma:
Zh
Revista:
Journal of Applied Clinical Pediatrics
Año:
1994
Tipo del documento:
Article